Please disable your adblock and script blockers to view this page

Aging and the immune system: Can it be reversed?


ancestors’
Immunology
TNF
Nature Reviews Immunology
Medical News Today
LADA


adults’

No matching tags


Mediterranean

No matching tags

No matching tags

No matching tags

Positivity     35.00%   
   Negativity   65.00%
The New York Times
SOURCE: https://www.medicalnewstoday.com/articles/immune-aging-and-how-to-combat-it
Write a review: www.medicalnewstoday.com
Summary

“Adaptive” immunity, which is responsible for remembering and attacking particular pathogens, steadily loses its ability to defend against viruses, bacteria, and fungi.Chronic, low-grade inflammation is associated with almost all conditions linked to older age, including type 2 diabetes, cardiovascular disease, cancer, and dementia. However, in older adults, this infection may steadily deplete their immune resources, making them more prone to other viral infections and reducing the effect of influenza immunizations.In addition to this slow decline in immunity with age, senescent T cells also produce more pro-inflammatory cytokines, such as IL-6. These, in turn, stoke the chronic, systemic inflammation of inflammaging.Although nothing can prevent aging, there are certain lifestyle changes a person can make to stay healthy into older age.The sections below will look at these factors in more detail.Exercise has a profound effect on the immune system, according to a recent overview of research in the journal Nature Reviews Immunology. Therefore, it makes sense that maintaining muscle mass through exercise protects against infection and conditions such as type 2 diabetes and cardiovascular disease, which are closely linked to chronic inflammation.One study found that aerobic fitness among 102 healthy males, aged 18–61 years, was inversely proportional to the number of senescent T cells in their blood after adjusting for age. As the authors of a review that appears in the journal Nature Reviews Immunology explain:“Taken together, these studies suggest that the emergence of certain features of immunosenescence and the extent of immune remodeling is likely to be heavily influenced by insufficient physical activity as humans age.”It is important to note that the majority of the research into the relationship between exercise and immunity in older adults has involved “cross-sectional” studies. Studies have suggested that older adults who exercise regularly and have a moderate weight have fewer senescent T cells and lower levels of pro-inflammatory cytokines in their blood.However, whether or not diet, exercise, and weight loss can reverse immunosenescence remains an open question for future research.There are more than 100 autoimmune diseases that scientists know about today.

As said here by https://www.medicalnewstoday.com/articles/immune-aging-and-how-to-combat-it