'Flexible DNA' may be key to overcoming fearful memories

Tim Bredy became intrigued by the brief periods during which Z-DNA structures exist, perhaps because it suggested a possible correspondence with the rapid changes in gene activity seen during the creation of fear-extinction memories.To investigate further, the researchers took a closer look at an enzyme called ADAR1. Finally, ADAR1 flips the DNA back into the more normal B-DNA structure.If the results of the mice experiments also apply to human beings, “It seems that the more easily you can switch between DNA structures,” says Marshall, “the more plastic your memory is.” “Flexibility of DNA structure, flexibility of memory.” – Dr. Paul MarshallBredy notes that the ability to feel fear and then successfully perform fear extinction is key to avoiding conditions such as PTSD and phobias.