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Inflammatory disorders: Does the immune system remember past infections?


Penn Dental Medicine
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Medical News Today


George Hajishengallis
Cell

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Positivity     39.00%   
   Negativity   61.00%
The New York Times
SOURCE: http://www.medicalnewstoday.com/articles/inflammatory-disorders-does-the-immune-system-remember-past-infections
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Summary

Bone marrow — or hematopoietic stem cell — transplants are an important therapy in the treatment of diseases such as leukemia, lymphoma, some types of cancer, and immune and blood disease.The study calls into question the role of transplants and whether they may transfer immune memory between donor and recipient.“If the concept that maladaptive inflammatory memory can be transmitted via bone marrow transplantation to naive recipient mice is confirmed in humans,” said Dr. Hajishengallis, “then clinicians may take inflammatory memory in the bone marrow into consideration when selecting appropriate donors for hematopoietic transplantation.”One of the findings of the study is the potential role of interleukin-1 (IL-1) signaling, a cytokine receptor that mediates inflammation in the immune system.The researchers found that when they blocked IL-1 signaling in mice with gum disease, the immune memory in their bone marrow no longer caused arthritis when transplanted to other mice.Hence, IL-1 may be useful in preventing misguided immune memory that triggers comorbidities.

As said here by Robby Berman