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Those with small- to medium-sized hands, which measure up to 7.5 inches, should get the standard M650, while those with hands longer than 7.5 inches should opt for the M650 L.If you have tiny hands and want a similar wireless mouse, there are smaller options, like the Razer Pro Click Mini (3.9×2.5×1.3 inches, 3.1 ounces with one battery).The medium-size version is 4.22×2.43×1.49 inches and 3.57 ounces. That makes it a bit smaller in length and width (but noticeably heavier) than Logitech's Pop Mouse (4.5×2.6×1.4 inches and 2.9 ounces), another wireless Logitech mouse with a $40 MSRP.The large M650 (4.65×2.58×1.63 inches, 3.92 ounces) is 10.19 percent longer and 9.8 percent heavier than the standard-sized version I tested. The similarly shaped and lower-priced Logitech M510 (4.72×2.56×1.6 inches, 4.55 ounces) is so heavy it feels clunky to use.There's a left-handed version of the M650—the side buttons are on the right side of the mouse—but it's only available in the large size.
As said here by Scharon Harding