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New psychosis treatment targets genetic mutation instead of symptoms


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the Medical News Today
the McLean Hospital
Biological Psychiatry
CNV
The National Institute of Mental Health
the University of Alabama
Healthline Media UK Ltd
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day.2019


Deborah L. Levy
Ph.D. —
Charity J. Morgan

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Inc.
the United States
Belmont
Abilify
Risperdal
Brighton
UK

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Positivity     33.00%   
   Negativity   67.00%
The New York Times
SOURCE: http://www.medicalnewstoday.com/articles/325731.php
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Summary

Healthline Media, Inc. would like to process and share personal data (e.g., mobile ad id) and data about your use of our site (e.g., content interests) with our third party partners (see a current list) using cookies and similar automatic collection tools in order to a) personalize content and/or offers on our site or other sites, b) communicate with you upon request, and/or c) for additional reasons upon notice and, when applicable, with your consent. Both were meant to boost the participants' glutamate function in hopes of alleviating their symptoms.These substances would not produce behavioral effects in healthy populations or those without a CNV of this particular gene.However, for the two participants who had this specific genetic mutation, the treatment alleviated their schizophrenia symptoms, improved their emotional engagement, and boosted their negative mood symptoms.It also helped decrease their tendency to withdraw from social situations.The National Institute of Mental Health define schizophrenia as "a chronic and severe mental disorder that affects how a person thinks, feels, and behaves." Symptoms often start in a person's mid-teens through age 30, and although rare, sometimes the condition can affect younger children, too.Symptoms fall under one of three categories: positive, negative, or cognitive.Positive symptoms can include:Negative symptoms are those that disrupt normal emotions and behaviors. Psychosocial treatments help people learn to cope with the challenges that schizophenia presents.The new study found a novel treatment for schizophrenia that is unique in psychiatry; most modern treatments target specific symptoms instead of genetic mutations.This type of treatment is contingent on a person having the mutations, of course, but this research helps pave the way for future treatments that can help people in different, and better, ways."Most studies of rare structural variants will have very small sample sizes, complicating the usual approach to statistical analysis," says study author Charity J.

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