Researchers discover neural patterns key to understanding disorders such as PTSD
Companies, agencies, institutions, etc
the University of California, Irvine
Alpha Rhythms
Amygdala-Hippocampal Circuit Supports Pattern Separation of Emotional Information
UCI School of Biological Sciences
UCI School of Medicine
the Neurobiology of Learning & Memory
UCI Henry Samueli School of Engineering
UCI Health
patients’
the National Institutes of Health
NIMH
the UCI School of Medicine
the Roneet Carmell Memorial Fund
the UCI Health Epilepsy Monitoring Unit
Association of American Universities
ISDN
2018Uncharted
People
Michael Yassa
yang
Jie Zheng
Jack J. Lin
Howard Gillman
Elizabeth Loftus
Ulysses MedalDecember
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Locations
Irvine
Calif.
PTSD
Orange County’s
communications.uci.edu/for-journalists
Dublin
2018Blocking
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Summary
Overamplified alpha rhythms from the amygdala to the hippocampus lead to faulty extrapolation of memories among similar experiences while balanced theta rhythms between the two brain regions promote correct discrimination and accurate recall.“The teamwork between the amygdala and hippocampus is like a yin and yang and may be the key to disentangle overlapping emotional experiences and to overcome overreactions in a similar situation,” said Jie Zheng, a UCI alumnus and the study’s first author.“Our findings provide a neural mechanism underlying this phenomenon and propose a circuit-level framework for possible neuropsychiatric therapy, such as deep brain stimulation, transcranial alternating current stimulation, and transcranial magnetic stimulation,” said Dr. Jack J.
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