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?Super antigens? tied to mysterious COVID-19 syndrome in children


National Geographic Society
National Geographic Partners
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CDC
MIS-C. Image
the NIAID Integrated Research Facility
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the U.S. Centers for Disease Control and Prevention
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the University of Texas Health Science Center
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the Center for Gut Microbiota Research
the Chinese University of Hong Kong
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Alvaro Moreira
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COVID-19
Hispanic
American
Indian

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MIS-C


Fort Detrick
Maryland
2020Count
U.S.
Boston
San Antonio
Italy
U.K.
Los Angeles
Hong Kong


Black, Indigenous

Positivity     38.00%   
   Negativity   62.00%
The New York Times
SOURCE: https://www.nationalgeographic.com/science/2020/10/super-antigen-tied-multisystem-inflammatory-syndrome-children-long-covid.html
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Summary

A recent report from the U.S. Centers for Disease Control and Prevention analyzed coronavirus fatalities in people under 21 and found that the majority were from MIS-C.“It happens so rapidly, and the kids are so ill, that 70 percent will require admission into an ICU,” says Alvaro Moreira, a physician scientist at the University of Texas Health Science Center at San Antonio who recently published an analysis of results from multiple scientific papers in EClinicalMedicine based on 662 cases of MIS-C.Even as clarity emerges around the early stages of the syndrome, questions are mounting about its true prevalence and its long-term outcomes. Arditi says, “We finally found the viral spike segment that may induce all those immune responses”—not only in MIS-C but possibly in adult COVID-19 cases.A new CDC study, largely overlooked because it came out the same weekend as President Trump’s COVID-19 diagnosis, shows that even adults with the virus can develop a severe condition similar to MIS-C. The report described 27 patients with “cardiovascular, gastrointestinal, dermatologic [skin], and neurologic symptoms without severe respiratory illness,” and called the condition MIS-A—for adults.Toxic shock has also long been associated with short- and long-term mental dysfunction, so Bahar wonders if the super antigen quality of SARS-CoV-2’s spike might also explain the high percentage of neurologic symptoms seen in adult COVID-19 patients. And he cautions that we don’t know the long-term implications.“We know that patients with Kawasaki disease can later develop aneurysms, thromboses, or blood clots, and have increased risk of high blood pressure and heart attacks at a younger age,” he says.The lasting consequences of the condition may fall unequally on Black, Indigenous, and people of color: Both Moreira’s review and the CDC report on MIS-C found that, as with adults who have the virus, racial disparities were clear.

As said here by Lois Parshley