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Type 1 diabetes cured in mice using stem cells


cured’
the Centers for Disease Control and Prevention
Washington University School of Medicine
scientists’
Nature Biotechnology
hPSC


Jeffrey R. Millman
Jeffrey Millman

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the United States
St. Louis
findings.“These

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The New York Times
SOURCE: http://www.medicalnewstoday.com/articles/type-1-diabetes-cured-in-mice-using-stem-cells
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Summary

He says, “A common problem when you’re trying to transform a human stem cell into an insulin-producing beta cell — or a neuron or a heart cell — is that you also produce other cells that you don’t want.” “In the case of beta cells, we might get other types of pancreas cells or liver cells.” While implanting these unnecessary — or “off-target” — cells does not cause any harm, Millman further explains that creating more of them offsets the number of therapeutically useful cells. The new stem cell protocol “can rapidly cure preexisting diabetes in mice,” they emphasize later on.The reversal occurred at a rate similar to that of human islets, and normal blood sugar control was maintained for at least 9 months.“We were able to make more beta cells, and those cells functioned better in the mice, some of which remained cured for more than a year.”– Jeffrey Millman The principal investigator continues to report on the highly significant findings.“These mice had very severe diabetes with blood sugar readings of more than 500 milligrams per deciliter of blood (mg/dL)— levels that could be fatal for a person — and when we gave the mice the insulin-secreting cells, within 2 weeks their blood glucose levels had returned to normal and stayed that way for many months.”However, the researcher also explains that there are a few more steps to follow before the research can help humans.

As said here by Ana Sandoiu